MedCalc: Duke Criteria for Infective Endocarditis
Durack DT, Lukes AS, Bright DK. New criteria for diagnosis of infective endocarditis: utilization of specific echocardiographic findings: Duke Endocarditis Service. Am J Med. 96:200-209, 1994.

Major criteria :
Positive blood culture for Infective Endocarditis
Typical microorganism consistent with IE from 2 separate blood cultures, as noted below:
•  viridans streptococci, Streptococcus bovis, or HACEK group (what's this?), or
•  community-acquired Staphylococcus aureus or enterococci, in the absence of a primary focus
or
Microorganisms consistent with IE from persistently positive blood cultures defined as:
•  2 positive cultures of blood samples drawn >12 hours apart, or
•  all of 3 or a majority of 4 separate cultures of blood (with first and last sample drawn 1 hour apart)
Evidence of endocardial involvement
Positive echocardiogram for IE defined as :
•  oscillating intracardiac mass on valve or supporting structures, in the path of regurgitant jets, or on implanted material in the absence of an alternative anatomic explanation, or
•  abscess, or
•  new partial dehiscence of prosthetic valve
or
New valvular regurgitation (worsening or changing of preexisting murmur not sufficient)

Minor criteria :
Predisposition: predisposing heart condition or intravenous drug use
Fever: temperature > 38.0 C (100.4 F)
Vascular phenomena: major arterial emboli, septic pulmonary infarcts, mycotic aneurysm, intracranial hemorrhage, conjunctival hemorrhages, and Janeway lesions
Immunologic phenomena: glomerulonephritis, Osler's nodes, Roth spots (what's this?), and rheumatoid factor
Microbiological evidence: positive blood culture but does not meet a major criterion as noted above¹ or serological evidence of active infection with organism consistent with IE
Echocardiographic findings: consistent with IE but do not meet a major criterion as noted above

¹ Excludes single positive cultures for coagulase-negative staphylococci, diphtheroids, and organisms that do not commonly cause endocarditis.

Duke Clinical Criteria for Infective Endocarditis:
Clinical criteria for infective endocarditis requires:
Two major criteria, or
One major and three minor criteria, or
Five minor criteria

References :

  • Durack DT, Lukes AS, Bright DK. New criteria for diagnosis of infective endocarditis: utilization of specific echocardiographic findings. Duke Endocarditis Service. American Journal of Medicine. 96(3):200-9, 1994.


Created: Sunday, July 15, 2001
Last Modified: